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外源性磷脂酶Ａ２（Ⅰ型ＰＬＡ２）和钙离子载体（Ａ２３１８７）可明显促进中性粒细胞对ＴＮＦ，ＦＭＬＰ的趋化及同玻璃球的粘附．ＰＬＡ２抑制剂二溴苯乙酮（ＰＢＰＢ）和ＰＬＡ２抗体对ＰＬＡ２诱发的趋化和粘附具有浓度相关的抑制作用，而对Ａ２３１８７的相同作用并无影响．提示ＰＢＰＢ和ＰＬＡ２抗体可能通过直接同ＰＬＡ２作用而抑制ＰＭＮ趋化和粘附，Ａ２３１８７诱导的促趋化及粘附作用可能不同于ＰＬＡ２．
Exogenous phospholipase A2 (type PLA2) and calcium ionophore (A23187) could obviously promote the chemotaxis of neutrophils to TNF and FMLP and adhesion with glass beads. PLA2 inhibitors dibromo acetophenone (PBPB) and PLA2 antibody had a concentration-dependent inhibitory effect on PLA2-induced chemotaxis and adhesion, but had no effect on the same effect of A23187. These results suggest that PBPB and PLA2 antibodies may inhibit PMN chemotaxis and adhesion by directly interacting with PLA2. The A23187-induced chemotaxis and adhesion may be different from that of PLA2.