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目的 明确严重急性呼吸综合征冠状病毒是否在北京疫区无偿献血人群中存在感染 ,为制订预防输血传播SARS的相关规定提供流行病学依据。方法 对 4 6 19份标本 (含SARS冠状病毒流行期北京疫区街头无偿献血人群血液筛查标本 2 35 7份 ,非流行期北京市街头无偿献血者人群留样标本 10 79份 ,流行期非疫区山东、湖南外调血无偿献血标本 1183份 ) ,作SARS冠状病毒IgM、IgG以及总抗体检测 ,对初筛阳性结果采用献血者追踪咨询和核酸检测的方法确认 ,用统计学方法分析最终的检测结果。结果 SARS流行期间北京疫区献血人群中未见SARS冠状病毒隐性感染者和出现流行感染情况。结论 预防经血传播SARS冠状病毒的重点应放在献血者征募和健康检查咨询方面 ,而非血液中SARS冠状病毒标记物的筛查。
Objective To determine whether SARS-CoV is infected in the blood donation group in Beijing epidemic area and to provide epidemiological basis for the development of SARS-related regulations for preventing blood transfusion. Methods A total of 2 367 samples (2 357 samples of blood donation on the streets of unmanufactured blood donors in Beijing epidemic area with SARS-CoV epidemic period, 10 79 samples of non-endemic Beijing street blood donors in non-epidemic period were collected, Blood samples were collected from 1183 donated blood donors in Shandong and Hunan Provinces for the detection of SARS coronavirus IgM, IgG and total antibodies. Positive results of primary screening were confirmed by follow-up of blood donors and nucleic acid testing. Statistical analysis of the final Test results. Results There was no SARS-CoV latent infection and epidemic infection in blood donors in Beijing epidemic area during SARS epidemic. Conclusion The prevention of blood-borne SARS-CoV should be focused on recruitment of blood donors and consultation on health check-ups rather than on screening for SARS-CoV markers in blood.