本文研究了哌唑嗪对四氯化碳致鼠肝纤维化发生发展的影响。结果表明。哌唑嗪预防组的门脉压(PVP1.343±0.167kPa)、肝静脉嵌塞压(WHVP 1.284±0.118kPa)、肝功能各项值分别与健康组比较,差异均无显著性意义;肝小叶间纤维束宽则显著低于葡萄糖组(P<0.05)。哌唑嗪治疗组PVP、WHVP,肝小叶间纤维束宽虽高于健康对照组,但显著低于葡萄糖组(P均<0.05).表明哌唑嗪有预防和延缓鼠肝纤维化发生、发展的作用。 This article studies the effect of prazosin on the development of liver fibrosis induced by carbon tetrachloride in rats. The results show. Prazosin prevention group portal pressure (PVP1.343 ± 0.167kPa), hepatic vein occlusion pressure (WHVP 1.284 ± 0.118kPa), liver function values ​​were compared with the healthy group, the difference was not significant; liver The bundle width of interlobular folds was significantly lower than that of glucose group (P <0.05). Prazosin treatment group PVP, WHVP, hepatic lobule fiber bundle width although higher than the healthy control group, but significantly lower than the glucose group (P <0.05), indicating that prazosin can prevent and delay the occurrence and development of rat liver fibrosis Role.