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目的:考察康复新液联合PPI治疗胃溃疡(GU)的疗效。方法:收集2011年5月~2014年6月在杭州市余杭区第五人民医院治疗的GU患者109例,随机分为2组,对照组51例,观察组58例。对照组给予泮托拉唑,观察组给予泮托拉唑和康复新液,治疗4周后比较两组患者疗效。结果:两组患者治疗前,炎症因子、TGF-β1、GAS、T淋巴亚群和血流动力学差异无统计学意义(P>0.05),治疗后两组患者以上指标均显著改善且观察组改善优于对照组(P<0.05)。观察组症状改善、溃疡愈合的总有效率及Hp根除率显著高于对照组(P<0.05)。两组患者治疗期间均无明显的不良反应。结论:康复新液具有降低炎症因子、改善血液动力学和提高免疫功能多方面作用,康复新液联合PPI治疗消化性溃疡疗效确切,安全,值得临床推广。
Objective: To investigate the curative effect of Kangfuxin solution combined with PPI on gastric ulcer (GU). Methods: A total of 109 patients with GU who were treated in the Fifth People’s Hospital of Yuhang District in Hangzhou from May 2011 to June 2014 were randomly divided into two groups: control group (n = 51) and observation group (n = 58). The control group was given pantoprazole, and the observation group was given pantoprazole and Kangfuxin solution. The curative effect of the two groups was compared after 4 weeks of treatment. Results: There was no significant difference in inflammatory factors, TGF-β1, GAS, T-lymphocyte subsets and hemodynamics between the two groups before treatment (P> 0.05). After treatment, the above indexes in both groups were significantly improved and the observation group Improve better than the control group (P <0.05). The observation group improved symptoms, the total effective rate of ulcer healing and Hp eradication rate was significantly higher than the control group (P <0.05). There was no significant adverse reaction during treatment in both groups. CONCLUSION: Kangfuxin solution has multiple roles in reducing inflammatory cytokines, improving hemodynamics and improving immune function. Kangfuxin and PPI are effective and safe in treating peptic ulcer, and worthy of clinical promotion.