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目的:观察润燥止痒胶囊、大黄虫丸内服联合卡泊三醇软膏外用治疗寻常型斑块状银屑病的疗效。方法:65例入选患者按随机数字表法分为两组,治疗组35例,对照组30例,治疗组口服润燥止痒胶囊4粒,3次/d,大黄虫丸3g,2次/d,同时外用卡泊三醇软膏,涂药后均采用聚已烯薄膜局部封包1h,2次/d,12周为1疗程,每2、4、8、12周复诊1次,观察皮疹治疗后变化及用药后不良反应的发生率,并由专人记录结果。对照组仅外用卡泊三醇软膏,每晚2次/d,方法及疗程同治疗组,1疗程后判定疗效。治疗前后均查血尿常规、肝肾功能、电解质、β2微球蛋白、血脂全套和心电图,以观察受试药物的安全性。结果:治疗组基愈率为74.29%,总有效率为91.43%;对照组基愈率为50%,总有效率为83.33%。两组基愈率经χ2检验,差异具有显著性(χ2=4.09,P<0.05),两组总有效率经χ2检验,差异具有显著性(χ2=4.93,P<0.05),表明治疗组临床疗效优于对照组。结论:润燥止痒胶囊、大黄虫丸内服联合卡泊三醇软膏外用治疗寻常型斑块状银屑病疗效确切。
Objective: To observe the effect of Moisturizing and Antipruritic Capsule and Rhubarb Pestle Oral Administration Combined with Calcipotriol Ointment for the Treatment of Vulvar Plaque Psoriasis. Methods: Sixty-five patients were randomly divided into two groups according to random number table: 35 cases in the treatment group and 30 cases in the control group. The treatment group was given 4 capsules of Runzaozhiyang capsule 3 times daily, d, at the same time external topical calcipotriol ointment, polyephedrine film are used after local coating 1h, 2 times / d, 12 weeks for a course of treatment, referral every 1, 2, 4, 8, 12 times to observe the rash treatment Post-treatment changes and the incidence of adverse reactions, and recorded by hand the results. Control group only topical calcipotriol ointment, night 2 times / d, method and course of treatment with the treatment group, a course of treatment to determine efficacy. Before and after treatment were checked hematuria, liver and kidney function, electrolyte, β2 microglobulin, blood lipid and ECG, in order to observe the safety of the test drug. Results: The healing rate of the treatment group was 74.29%, the total effective rate was 91.43%. The control group was 50%, the total effective rate was 83.33%. Two groups of healing rate by χ2 test, the difference was significant (χ2 = 4.09, P <0.05), the total effective rate of the two groups by χ2 test, the difference was significant (χ2 = 4.93, P <0.05), indicating that the treatment group clinical Efficacy than the control group. Conclusion: Runzaozhi itch capsule, rhubarb worm pill orally combined with calcipotriol ointment for the treatment of vulvar psoriasis vulgaris exact effect.