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本文通过透射电流观察了LAK 细胞与肿瘤细胞在不同的作用时期的超微结构病理过程。结果表明,LAK 细胞与肿瘤细胞混合15分钟后即可发生膜接触,30分钟后与肿瘤细胞紧密接触并融合,融合处肿瘤细胞胞浆发生空泡,4小时后LAK 细胞已进入肿瘤细胞内。作者提出脾LAK 细胞杀伤瘤细胞的病理过程。
In this paper, the ultrastructural pathological process of LAK cells and tumor cells at different stages of action was observed by transmission current. The results showed that LAK cells could contact with tumor cells for 15 minutes and contact with tumor cells 30 minutes later. The cells in the cytoplasm of fusion cells were vacuolized. After 4 hours, LAK cells had entered the tumor cells. The authors propose the pathological process of splenic LAK cells killing tumor cells.