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Survivin基因是迄今为止发现的最强的抑制细胞凋亡的基因,同时其还具有调节细胞增殖及参与血管生成的作用。Survivin基因的特异性表达不仅可以作为诊断涎腺腺样囊性癌(ACC)的新型指标,还可以作为判定涎腺ACC预后的指标。本文就Survivin基因在涎腺ACC的发病机制中的研究进展进行综述。
Survivin gene is by far the strongest inhibition of apoptosis genes, but it also has the role of regulating cell proliferation and involved in angiogenesis. The specific expression of Survivin gene can not only be used as a new diagnostic indicator of salivary adenoid cystic carcinoma (ACC), but also as an indicator of the prognosis of salivary gland ACC. This review summarizes the research progress of Survivin gene in the pathogenesis of ACC in salivary glands.