论文部分内容阅读
目的探讨氨溴索对肺癌患者放射性肺损伤的保护作用。方法进展期肺癌放射治疗(放疗)患者120例随机均分为两组:A组放疗期间静脉滴注氨溴索90mg/d,连续20d;B组单纯放疗。放疗前后测定TNF-α和转化生长因子β1(TGF-β1)水平。观察临床症状、肺一氧化碳弥散量(DLCO)和肺部影像学改变。结果放疗后,A组DLCO下降幅度小于B组(P<0.05),放射性肺纤维化发生率也低于B组(P<0.05)。放疗后,A组血浆TNF-α和TGF-β1表达量均低于B组[(2.43±0.83)ng/ml vs.(5.62±2.64)ng/ml和(5.56±1.21)ng/ml vs.(11.83±5.54)ng/ml](P<0.01)。两组患者均未出现明显肝、肾损害等不良反应。结论氨溴索可能通过抑制放疗后血浆TNF-α和TGF-β1的过度表达而减轻肺癌患者放射性肺损伤。
Objective To investigate the protective effect of ambroxol on radiation-induced lung injury in patients with lung cancer. Methods 120 cases of advanced lung cancer radiotherapy (radiotherapy) patients were randomly divided into two groups: A group during the intravenous infusion of ambroxol 90mg / d, continuous 20d; B group radiotherapy alone. The levels of TNF-α and TGF-β1 were measured before and after radiotherapy. Clinical symptoms, diffuse lung carbon monoxide (DLCO) and lung imaging changes were observed. Results After radiotherapy, the decrease of DLCO in group A was less than that in group B (P <0.05), and the incidence of radiation pulmonary fibrosis was also lower than that in group B (P <0.05). After radiotherapy, the expression of TNF-α and TGF-β1 in group A were lower than those in group B [(2.43 ± 0.83) ng / ml vs. (5.62 ± 2.64) ng / ml vs (5.56 ± 1.21) ng / ml vs. (11.83 ± 5.54) ng / ml] (P <0.01). Two groups of patients did not appear obvious liver and kidney damage and other adverse reactions. Conclusion Ambroxol may attenuate radiation-induced lung injury in lung cancer patients by inhibiting the over-expression of plasma TNF-α and TGF-β1 after radiotherapy.