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目的研究复发性阿弗他溃疡患者发病期与无症状期时机体的总抗氧化能力(total antioxidant capacity,T-AOC)含量变化,并与健康人群的T-AOC进行比较,分析T-AOC与复发性阿弗他溃疡发病机制间的关系。方法选取97例确诊为轻型复发性阿弗他溃疡的患者和102名健康人为研究对象。分别在患者发病期(A1组)和无症状期(A2组)抽取5ml空腹静脉血,以健康人空腹静脉血为对照组(B组)。采用色度法检测机体血清T-AOC水平。结果B组T-AOC血清含量为3.01±0.54mmol Trolox Eq/L,显著高于A1组(2.38±0.75mmol Trolox Eq/L;P=0.008<0.05)。A2组T-AOC血清含量最高(3.05±0.65mmol Trolox Eq/L),与B组无统计学差异(P=0.885>0.05)。结论血清T-AOC变化与复发性阿弗他溃疡的发病机制存在一定相关性。
Objective To study the changes of total antioxidant capacity (T-AOC) in patients with recurrent aphthous ulcer at onset and asymptomatic periods, and to compare with the T-AOC in healthy subjects. Relationship between the pathogenesis of recurrent aphthous ulcer. Methods A total of 97 patients with mild recurrent aphthous ulcer and 102 healthy individuals were selected as the study subjects. Fasting venous blood (5ml) was drawn in patients with onset stage (A1) and asymptomatic stage (A2), and healthy volunteers as control group (B). The colorimetric method was used to detect the serum T-AOC level. Results Serum T-AOC in group B was 3.01 ± 0.54 mmol Trolox Eq / L, which was significantly higher than that in group A1 (2.38 ± 0.75 mmol Trolox Eq / L; P = 0.008 <0.05). The serum T-AOC level of A2 group was the highest (3.05 ± 0.65 mmol Trolox Eq / L), but there was no significant difference with that of B group (P = 0.885> 0.05). Conclusions The change of serum T-AOC has a certain correlation with the pathogenesis of recurrent aphthous ulcer.