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目的:评价西地那非用于治疗新生儿持续性肺动脉高压症患儿的临床疗效。方法:选取新生儿持续性肺动脉高压症患儿82例,将其分为治疗组和对照组,每组41例;对照组患儿均给予常规对症治疗,治疗组患儿在对照组患儿治疗基础上加用西地那非治疗,评价两组患儿治疗后的临床疗效。结果:治疗组患儿治疗后PaO_2指标值显著高于对照组患儿(P<0.05);治疗组患儿PaCO_2和SPAP指标值显著低于对照组(P<0.05);治疗组患儿治疗后呼吸机的使用时间、住院时间和临床总有效率分别为(59.68±12.04)h,(10.02±2.34)d,92.68%优于对照组分别为(78.67±11.51)h,(12.35±3.26)d和73.17%(P<0.05)。结论:西地那非用于治疗新生儿持续性肺动脉高压症的临床疗效优于常规治疗。
Objective: To evaluate the clinical efficacy of sildenafil in the treatment of neonates with persistent pulmonary hypertension. Methods: 82 cases of newborn persistent pulmonary hypertension were selected and divided into treatment group and control group, 41 cases in each group. The control group of children were given conventional symptomatic treatment, the treatment group of children in the control group of children with treatment Based on the use of sildenafil treatment, evaluation of two groups of children after treatment of clinical efficacy. Results: The PaO 2 index of the treatment group was significantly higher than that of the control group (P <0.05). The PaCO 2 and SPAP values of the treatment group were significantly lower than those of the control group (P0.05) The duration of use of ventilator, hospital stay and total effective rate were (59.68 ± 12.04) h and (10.02 ± 2.34) days, respectively, which were significantly higher than those in the control group (92.68% vs 78.67 ± 11.51 and 12.35 ± 3.26, respectively And 73.17% (P <0.05). Conclusion: The efficacy of sildenafil in the treatment of persistent pulmonary hypertension in neonates is superior to conventional treatment.