Amicoumacin类抗生素是由微生物产生的异香豆素类化合物,其化学结构独特,生物活性广泛,是微生物药物的重要来源。自1975年第一个明确化合物结构的amicoumacin类化合物报道至今,国内外尚无该类化合物研究进展的综述。针对国内外amicoumacin类化合物研究进展结合本课题组最新研究结果,本文首次对该类化合物产生菌来源、化合物结构、生物活性和生物合成途径等各方面进展进行了较全面的总结。 Amicoumacin antibiotics are isocoumarins produced by microorganisms, its unique chemical structure, wide range of biological activity, is an important source of microbial drugs. Since the first compound structure of amicoumacin was reported in 1975, there is no review on the research progress of this compound at home and abroad. Aims at the research progress of amicoumacin compounds at home and abroad combined with the latest research results of this group, this article for the first time made a comprehensive summary of various aspects of the origin of the compounds such as bacteria origin, compound structure, biological activity and biosynthesis pathway.