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目的研究生殖道支原体感染与女性不孕不育之间的关系,分析其耐药情况。方法采用培养的方法对我院生殖中心就诊的不孕不育女性患者宫颈分泌物进行检测。结果不孕不育组的Uu、Mh感染率与对照组比较有显著差异(P<0.05),明显高于对照组;对喹诺酮类药物氧氟沙星(OFL)、左氧氟沙星(LEV)和司帕沙星(SPA)的耐药率呈较高水平,大环内酯类药物阿奇霉素(AZI)和罗红霉素(ROX)耐药率较高,尤其在解脲脲原体(Uu)+人型支原体(Mh)混合感染中,喹诺酮类和大环内酯类的耐药率均在高水平状态,四环素类抗生素在混合感染中耐药率显著上升。结论女性不孕不育与生殖道支原体感染有密切的关系,强力霉素(DOX)、美满霉素(M IN)和交沙霉素(JOS)为治疗支原体的首选药物。
Objective To study the relationship between mycoplasma genitalium infection and female infertility and to analyze its drug resistance. Methods The methods of culture were used to detect the cervical secretions of infertile women who were treated in the reproductive center of our hospital. Results The infection rate of Uu and Mh in infertility group was significantly higher than that in control group (P <0.05), which was significantly higher than that in control group. Infections of OFL, LEV, The drug resistance rate of the sand star (SPA) was high, and the resistance rates of macrolide azithromycin (AZI) and roxithromycin (ROX) were high, especially in Uu + Mycoplasma (Mh) mixed infections, quinolones and macrolides resistant rates were high, the tetracycline antibiotic resistance rates in mixed infections increased significantly. Conclusion Female infertility is closely related to genital mycoplasma infection. DOX, M IN and JOS are the first choice drugs for the treatment of mycoplasma.