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目的探讨外阴湿疣和宫颈炎症与宫颈人乳头状瘤病毒(HPV)亚临床感染(SPI)之间的相关性,为预防HPV感染提供依据。方法选取2012年6月-2013年9月126例接受治疗的患者作为研究对象,根据病因分为外阴湿疣组69例和宫颈炎症组57例,选取同期正常女性50名作为对照组;采用阴道镜检查并镜下取组织进行病理诊断,以判断是否有HPV亚临床感染;同时对3组个体镜下所取组织标本进行荧光定量PCR检测、HC2-HPV-DNA检测,以判断个体是否有高危型HPV感染,并对患者进行密切随访。结果外阴湿疣组与宫颈炎症组患者HPV亚临床感染分别为36、13例,感染率52.17%、22.81%,两者之间差异有统计学意义(P<0.05),两组感染率与对照组相比,差异有统计学意义(χ2=30.95、7.82,P<0.01);通过杂交捕获试验,外阴湿疣组、宫颈炎症组与对照组高危HPV感染分别为29、15、4例,高危HPV感染率分别为42.03%、26.32%与8.00%,外阴湿疣组与宫颈炎症组患者之间差异无统计学意义,但与对照组相比,差异有统计学意义(χ2=16.75、6.12,P<0.05)。结论外阴湿疣、宫颈炎症患者宫颈HPV亚临床感染率和高危HPV感染率高于正常人群,要高度关注外阴湿疣和宫颈炎症患者,做好随访和宣传工作,以预防由HPV感染引起的其他妇科疾病的发生。
Objective To investigate the relationship between genital warts and cervix inflammation and cervical subclinical infection of human papillomavirus (HPV), and provide basis for preventing HPV infection. Methods A total of 126 patients treated from June 2012 to September 2013 were selected as study subjects. According to the cause, 69 cases were treated with vulvar condyloma acuminatum and 57 cases with cervicitis. Fifty normal women were selected as the control group. Check and take the tissue under the microscope pathological diagnosis to determine whether there is HPV subclinical infection; at the same time on the 3 groups of individual tissue samples taken by fluorescence quantitative PCR detection, HC2-HPV-DNA test to determine whether the individual is high-risk type HPV infection, and close follow-up of patients. Results The HPV subclinical infections in genital warts and cervicitis patients were 36 and 13, respectively, with the infection rates of 52.17% and 22.81%, respectively. There was a significant difference between the two groups (P <0.05) (Χ2 = 30.95, 7.82, P <0.01). By hybridization capture test, the high risk HPV infection in genital warts group, cervicitis group and control group were 29,15 and 4 cases, respectively. High risk HPV infection The rates were 42.03%, 26.32% and 8.00% respectively. There was no significant difference between genital warts and cervicitis patients, but the difference was statistically significant (χ2 = 16.75, 6.12, P <0.05) ). Conclusions The genital warts and cervical inflammation patients have a higher rate of HPV infection in the cervical HPV and a higher risk of HPV infection than those in the normal population. They should pay close attention to genital warts and cervicitis patients, follow up and advocacy efforts to prevent other gynecological diseases caused by HPV infection happened.