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Two-dimensional boundary layer flow of an incompressible third grade nanofluid over a stretching surface is investigated. Influence of thermophoresis and Brownian motion is considered in the presence of Newtonian heating and viscous dissipation. Goving nonlinear problems of velocity, temperature and nanoparticle concentration are solved via homotopic procedure. Convergence is examined graphically and numerically. Results of temperature and nanoparticle concentration are plotted and discussed for various values of material parameters, Prandtl number, Lewis number, Newtonian heating parameter, Eckert number and thermophoresis and Brownian motion parameters. Numerical computations are performed. The results show that the change in temperature and nanoparticle concentration distribution functions is similar when we use higher values of material parametersβ1 andβ2. It is seen that the temperature and thermal boundary layer thickness are increasing functions of Newtonian heating parameterγ. An increase in thermophoresis and Brownian motion parameters tends to an enhancement in the temperature.