有关神经母细胞瘤的染色体核型已有不少报道,但极少取自早期肿瘤组织,其原因可能在于早期患者难于发现。1984年,Sa-wada等人在日本进行了婴儿神经母细胞瘤的普查工作,为早期神经母细胞瘤的研究提供了材料。Look等人用流式细胞计数法研究了35例婴儿的神经母细胞瘤的DNA含量,发现超二倍体现象在早期肿瘤中比在晚期肿瘤中普遍。还有人发现N-myc的扩增与肿 There have been many reports on the karyotype of neuroblastoma, but very few are derived from early stage tumors. The reason may be that early patients are difficult to find. In 1984, Sa-wada et al. conducted a survey of infant neuroblastomas in Japan and provided materials for the study of early neuroblastomas. Look et al. used flow cytometry to study the DNA content of neuroblastoma in 35 infants and found that the hyperdiploid phenomenon was more prevalent in early tumors than in advanced tumors. Others have also found that N-myc is amplified and swollen