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目的探讨卒中后抑郁障碍与血管性危险因素的相关性。方法选择在卒中专病门诊连续就诊的资料完整的卒中初诊患者1055例,按有无抑郁障碍分为抑郁组和非抑郁组(对照组)两组。收集并比较两组患者的血管性危险因素。结果 1055例患者中,291例(27.6%)有抑郁障碍。抑郁障碍者的高血压史、心脏病史、高脂血症史、既往卒中史、高血压家族史和心脏病家族史的比例显著高于无抑郁障碍者(P均<0.05),而吸烟史、饮酒史、糖尿病史及卒中家族史无显著统计学差异。抑郁障碍者的血管危险因素个数明显多于无抑郁障碍组(P<0.01)。多因素Logistic回归分析显示高血压史(RR1.615,95%CI1.135～2.298,P=0.008)、高脂血症史(RR2.085,95%CI1.490～2.918,P<0.01)、既往卒中史(RR1.443,95%CI1.034～2.014,P=0.031)和心脏病家族史(RR1.844,95%CI1.228～2.769,P=0.003)是卒中后抑郁的独立相关因素。结论卒中专病门诊患者的卒中后抑郁障碍患病率高。多种血管性危险因素和其数目是卒中后抑郁障碍的独立危险因素。
Objective To investigate the relationship between post-stroke depression and vascular risk factors. Methods A total of 1055 newly diagnosed stroke patients were selected as follow-up data of stroke clinic. The patients were divided into depression group and non-depression group (control group) according to the presence or absence of depression. Vascular risk factors were collected and compared between the two groups. Results Of the 1055 patients, 291 (27.6%) had depressive disorders. The history of hypertension, heart disease, history of hyperlipidemia, previous history of stroke, family history of hypertension and family history of heart disease in depressive patients were significantly higher than those without depressive disorders (all P <0.05) Alcohol consumption history, history of diabetes and stroke family history no significant difference. The number of vascular risk factors in depressive patients was significantly higher than that in patients without depressive disorders (P <0.01). Multivariate Logistic regression analysis showed that the history of hypertension (RR1.615, 95% CI1.135-2.298, P = 0.008), history of hyperlipidemia (RR2.085, 95% CI1.490-2.918, P <0.01) Previous stroke history (RR1.443, 95% CI1.034-2.014, P = 0.031) and family history of heart disease (RR1.844, 95% CI1.228-2.769, P = 0.003) were independent risk factors for post-stroke depression . Conclusions The prevalence of post-stroke depression is high in outpatients with stroke special disease. Multiple vascular risk factors and their numbers are independent risk factors for post-stroke depression.