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目的观察早期目标导向治疗(EGDT)治疗脓毒性休克的临床疗效。方法将符合病例入选标准的80例脓毒性休克患者随机分为观察组、对照组,每组40例。对照组在积极控制原发性感染的基础上,给予晶体液、胶体液或白蛋白等进行常规液体扩容循环与容量支持治疗,同时应用血管活性药物。观察组给予早期目标导向疗法治疗。结果CVP、MAP、ScvO2、SOFA评分、APACHEⅡ评分等指标治疗前后相比,差异有统计学意义(P﹤0.05);治疗后组间相比,差异有统计学意义(P﹤0.05)。第7 h尿量观察组大于对照组,2组比较差异有统计学意义(P﹤0.05);住ICU时间观察组短于对照组,2组比较差异有统计学意义(P﹤0.05);住院病死率观察组为15.00%,对照组为52.50%,2组比较差异有统计学意义(P﹤0.05)。结论早期目标导向疗法可显著改善血流动力学指标及APACHEⅡ评分、器官衰竭评分(SOFA),可降低病死率。
Objective To observe the clinical efficacy of early goal-directed therapy (EGDT) in the treatment of septic shock. Methods A total of 80 patients with septic shock who met the criteria of the selected cases were randomly divided into observation group and control group, 40 cases in each group. Control group in the active control of primary infection, based on the given liquid crystal, colloidal fluid or albumin and other conventional liquid dilatation circulation and volume support treatment, while the application of vasoactive drugs. The observation group was given early goal-directed therapy. Results The CVP, MAP, ScvO2, SOFA score, APACHE Ⅱ score and other indicators before and after treatment were significantly different (P <0.05). There was significant difference between the two groups after treatment (P <0.05). (P <0.05). The ICU observation group was shorter than the control group, the difference between the two groups was statistically significant (P <0.05); hospitalization The mortality was 15.00% in the observation group and 52.50% in the control group, with significant difference between the two groups (P <0.05). Conclusion Early goal-directed therapy can significantly improve hemodynamic parameters and APACHE Ⅱ score, organ failure score (SOFA), can reduce the mortality.