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为寻找恶性疟原虫基因工程多表位疫苗保护性评价的模型动物,利用鼠约氏疟原虫（Plasmodium yoelii）及伯氏疟原虫小鼠（Phasmodium bergher）模型对本实验室构建的恶性疟原虫（Plasmodium falciparum）多表位基因工程候选疫苗进行了体内保护性及免疫模式试验。结果在约氏疟原虫,先用该疫苗基因的大肠杆菌表达蛋白免疫、后用含同一基因的重组痘苗病毒加强免疫组与野生型痘苗病毒免疫组及空白对照相比,小鼠的死亡时间延长（P<0.01）。结果初步显示,约氏疟原虫鼠模可用作该基因工程多表位恶性疟原虫候选疫苗的保护性评价。
In order to find a model animal for the protective evaluation of Plasmodium falciparum genetic engineering polyepitope vaccine, Plasmodium falciparum (Plasmodium falciparum) constructed by our laboratory was constructed using Plasmodium yoelii and Phasmodium bergher models. falciparum) polytope genetic engineering candidate vaccine in vivo protective and immune model tests. The results of the vaccine in Plasmodium yoelii, the first use of the vaccine gene expressed in E. coli protein immunized with recombinant vaccinia virus containing the same gene boosted group and wild-type vaccinia virus-immunized group and blank control, the mice died longer (P <0.01). The results initially showed that P. yoelii murine models could be used as a protective evaluation of the genetically engineered polytopenoid Plasmodium falciparum vaccine candidate.