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观察90例不同血脂水平的职工,发现高血脂者血清丙二醛(MDA)水平明显高于正常血脂者(P<0.001),而红细胞超氧化物歧化酶(SOD)活性两者间无明显差异(P>0.05)。多元回归分析表明,MDA仅与血清非高密度脂蛋白胆固醇呈正相关,而SOD仅与高密度脂蛋白胆固醇呈正相关。高血脂者经调节血脂治疗后,MDA明显下降,而SOD无明显变化,提示高脂血症与脂质过氧化间有一定关系。
90 workers with different blood lipid levels were observed. The level of malondialdehyde (MDA) in serum of hyperlipidemia patients was significantly higher than that of normal blood lipids (P <0.001), while the activity of erythrocyte superoxide dismutase (SOD) showed no significant difference (P> 0.05). Multivariate regression analysis showed that MDA was positively correlated with serum non-HDL cholesterol, while SOD was positively correlated with HDL cholesterol only. Hyperlipidemia after treatment of lipid-lowering therapy, MDA decreased significantly, while no significant changes in SOD, suggesting that hyperlipidemia and lipid peroxidation have a relationship.