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目的了解恶性肿瘤患者的人芽囊原虫感染情况及临床特点,为采取相应的防治措施提供依据。方法对2013年4月-2014年4月广西医科大学第一附属医院和肿瘤医院683例恶性肿瘤住院患者,进行人芽囊原虫的病原学检查,并分析感染情况。结果受检者人芽囊原虫感染112例(16.40%),其中黏液脓血便组(A组)的感染率显著高于其他类型粪便组(P<0.001);不同性别、年龄间感染率差异无统计学意义(P>0.05);在不同治疗组中,化疗组的感染率最高,为26.40%;在不同肿瘤类别组中,消化系统组的感染率最高,为28.51%;低白蛋白组感染率显著高于白蛋白正常组(P<0.001);免疫功能低下组感染率显著高于免疫功能正常组(P<0.001)。结论恶性肿瘤患者中存在一定程度的人芽囊原虫感染,应及时诊治,以防贻误病情。
Objective To understand the infection and clinical features of human Blastocystis protozoa in patients with malignant tumors and to provide evidence for the corresponding prevention and treatment measures. Methods From April 2013 to April 2014, 683 inpatients with malignant tumors in the First Affiliated Hospital of Guangxi Medical University and Cancer Hospital were enrolled in the etiological examination of Blastocystis protozoa and the infection was analyzed. Results Infection of 112 cases (16.40%) occurred in the test group, in which the infection rate of mucous sepsis group (A group) was significantly higher than that of other types of feces group (P <0.001). There was no significant difference in infection rate between different sex and age groups (P> 0.05). In the different treatment groups, the infection rate was the highest in the chemotherapy group (26.40%). In the different tumor groups, the infection rate in the digestive system group was the highest (28.51%), and the infection rate in the low albumin group (P <0.001). The infection rate in the immunocompromised group was significantly higher than that in the normal immunocompetent group (P <0.001). Conclusion There is a certain degree of infection of human Blastocystis protozoa in the patients with malignant tumors, and timely diagnosis and treatment should be done to prevent delaying the disease.