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新近研究表明,在慢性炎症组织中,参与免疫应答的是发生T细胞受体(TCR)重排并表达的优势淋巴细胞群.在恶性肿瘤中,参与免疫应答的也是受选择性抗原刺激发生TCR基因重排或具有相同TCR可变区的优势T淋巴细胞群.该文主要对肿瘤浸润淋巴细胞(TIL)的TCR-β链基因重排进行了研究.
Recent studies have shown that in chronic inflammatory tissues, immune response involves a predominant lymphocyte population with T cell receptor (TCR) rearrangement and expression. In malignant tumors, the TCR is also stimulated by selective antigens in the immune response. Gene rearrangement or predominant T lymphocyte population with the same TCR variable region. This article mainly studied TCR-β chain gene rearrangement of tumor infiltrating lymphocytes (TIL).