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目的 了解医院肺真菌感染的临床特征及药物敏感状态。方法 对医院肺真菌感染危险因素、诊断、抗真菌药物敏感性及疗效进行分析。结果 10 5例肺真菌感染者均有严重基础疾病 ,81例 (77.14% )用过抗生素 ,临床表现无特异性 ,对有呼吸道症状者及时作痰培养确诊 ;培养出真菌 111株 ,白色念珠菌及热带念珠菌分别为 71.17%及 10 .81% ;抗真菌药物敏感性分别为 AMB 5 6 .19%、5 - FC 5 5 .2 4%、KCZ 6 1.90 %、NYS 3 1.43%及 FCZ 6 4.76 % ;氟康唑治疗有效率80 .85 %。结论 严重基础病及长期用抗生素者肺部真菌感染率较高 ,积极治疗原发病、合理使用抗生素及肾上腺皮质激素等有利于预防肺部真菌感染 ,氟康唑治疗有效
Objective To understand the clinical features and drug sensitivity of pulmonary fungal infection in hospitals. Methods The risk factors, diagnosis, anti-fungal sensitivity and efficacy of pulmonary fungal infection in hospitals were analyzed. Results 105 patients with pulmonary fungal infection had serious underlying diseases, 81 (77.14%) used antibiotics, the clinical manifestations of nonspecific, timely diagnosis of respiratory symptoms and sputum culture; out of 111 strains of fungi, Candida albicans And Candida tropicalis were 71.17% and 10.81%, respectively. The antifungal drug sensitivity were AMB5.6.19%, 5-FC5.5.24%, KCZ6 1.90%, NYS3 1.43% and FCZ6 4.76%; fluconazole treatment efficiency of 80.85%. Conclusions Serious pulmonary fungal infection is found in patients with severe basic diseases and long-term antibiotics. Active treatment of the primary disease, rational use of antibiotics and adrenocorticotropic hormone are good for the prevention of pulmonary fungal infection and fluconazole treatment is effective