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本文应用免疫荧光及免疫酶标技术,分别对188例及96例系膜性IgA肾病肾组织内免疫沉积物进行分析;着重对免疫球蛋白沉积类型、IgA沉积部位与临床表现,组织形态改变的关系作了探索。发现免疫球蛋白沉积类型差异,可能与本病临床表现的多样化、组织形态改变轻重不一的特点存在一定的联系。IgA型的临床表现,组织病变明显轻于IgAGM型,两型间肉眼血尿发生率、蛋白尿程度、硬化病变发生率、间质病变程度,相差显著或非常显著;IgAG型与IgAM型的临床表现、组织病变,介于IgA型与
Immunofluorescence and enzyme-linked immunosorbent assay were used to analyze the immunological deposits in 188 cases and 96 cases of mesangial IgA nephropathy, respectively. The immunoglobulin deposition types, IgA deposition sites and clinical manifestations, histological changes The relationship has been explored. Found that the type of immunoglobulin deposition differences may be related to the clinical manifestations of this disease diversification, the characteristics of varying degrees of tissue morphology there is a link. IgA type of clinical manifestations, histological lesions were significantly lighter than IgAGM type, the incidence of gross hematuria between two types of type, proteinuria, sclerosis, interstitial lesions, the difference was significant or very significant; IgAG type and IgAM clinical manifestations , Tissue lesions, between IgA type and