论文部分内容阅读
肠易激综合征( IBS)患者常伴有轻中度抑郁状态，且肠黏膜可能存在低度炎症，目前多种化学合成抗抑郁药物已用于IBS的治疗。贯叶金丝桃是一种治疗轻中度抑郁的植物药，同时还具有减轻肠黏膜炎症反应和镇痛等作用。贯叶金丝桃及其制剂用于IBS治疗已有越来越多的报道，多数肯定其疗效，并且安全性优于其他传统抗抑郁药物。该文就贯叶金丝桃及其制剂治疗IBS的可能机制、临床研究进展及安全性进行综述。“,”Irritable bowel syndrome(IBS) is closely associated with mild depression,while intestinal low-grade inflammation is believed playing a key role in the development of IBS,and antidepressive drugs have been applied to clinical treatment at present. Hypericumperforatum is a herb for treatment of moderate depression,which also has an effect on reducing the inflammatory reaction of intestinal mucosa and analgesia. The possible therapeutic efficacy and safety of hypericumperforatum on IBS have been manifested by clinical observation. Here reviews the research updates on the potential mechanisms,available clinical trials and the safety issues of hypericumperforatum on IBS treatment.