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除1967年Engel等曾见1例6岁APL女孩,有17或18号染色体长臂缺失外,新近Rowley等应用染色体分带技术,首次发现2例APL均有17号染色体长臂近侧端(在中间部位)明显缺失,即[del(17)(q11 q21或22)]。并且最近又报告第3例APL也是如此,同时指出以上3例的核型中都还有异常的15号染色体,其长臂的中部有一个显著的暗带。Rowley认为,断裂发生于15号染色体的15q22带的位置,17号染色体的17q21带插入断裂的15号染色体,核型表达为[46,XY,ins(15;17)(q22?;q21?)]。另外,Okada和Sakurai等也各报告1例APL有上述15号和17号染色体异常,但他们认为系15号和17号染色体长臂相互易位的结果,而不是Rowley所解释的“插入”。因为异常的15号染色体的长臂与正常15号染色体相比,其末端带更明亮,而异常的17号染色体长臂的末端带不如正常17号染色体明亮。他们对畸变的核型的命名是[46,XX,t(15;17)(q22;q21)]。Okada考虑,17号染色体长臂的17q21带
In addition to a 6-year-old APL girl who had seen a case of 6-year-old APL in 1967 and who had missing the long arm of chromosome 17 or 18, recently Rowley et al. Applied chromosome partitioning to detect APL in chromosome 17 on the 17th chromosome In the middle) is significantly missing, ie [del (17) (q11 q21 or 22)]. And recently reported a third case of APL is also true, also pointed out that the karyotype of the above three cases are still abnormal chromosome 15, the middle of the long arm has a significant dark zone. According to Rowley, the cleavage occurred at position 15q22 on chromosome 15 and the 17q21 band on chromosome 17 had a cleaved chromosome 15 with the karyotype expressed as [46, XY, ins (15; 17) (q22?; Q21?) ]. In addition, Okada and Sakurai et al. Each reported 1 case of APL with chromosomal abnormalities 15 and 17 described above, but they concluded that the long arms of chromosomes 15 and 17 were translocated to each other rather than “inserted” as Rowley interpreted. Because the abnormal long arm of chromosome 15 has a brighter end band than normal chromosome 15, the terminal band of the abnormal long arm of chromosome 17 is not as bright as the normal chromosome 17. Their naming of distorted karyotypes is [46, XX, t (15; 17) (q22; q21)]. Okada considered the 17q21 band on chromosome 17 long arm