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目的探讨白细胞介素!6(IL!6)在吉兰!巴雷综合征(Guillian!Barre Syndrome,GBS)发病及诊断中的作用。方法采用ELISA法测定GBS患者急性期和恢复期脑脊液中IL!6水平,并与正常人脑脊液对照。结果36例成人GBS患者脑脊液IL!6水平为(36.88±9.26)×1012kU/L;26例正常对照组为(14.97±8.68)×1012kU/L;成人GBS组脑脊液IL!6水平明显高于正常对照组,P<0.01。18例成人GBS患者脑脊液IL!6治疗前水平为(33.57±5.0)×1012kU/L,治疗后水平为(13.55±8.03)×1012kU/L,较治疗前明显下降(P<0.01)。但病情轻重各级之间脑脊液IL!6水平无显著性差异。结论IL!6参与GBS的病理过程,但与病情轻重无明显关系。
Objective To investigate the role of interleukin-6 (IL-6) in the pathogenesis and diagnosis of Guillain-Barre Syndrome (GBS). Methods IL-6 levels in cerebrospinal fluid (CSF) of acute and convalescent GBS patients were determined by ELISA, and compared with normal cerebrospinal fluid. Results The levels of IL-6 in cerebrospinal fluid (36.88 ± 9.26) × 1012kU / L in 36 adults with GBS were (14.97 ± 8.68) × 1012kU / L in 26 patients with normal controls and significantly higher than those in controls The levels of IL-6 in cerebrospinal fluid of adult GBS patients before treatment were (33.57 ± 5.0) × 1012kU / L and (13.55 ± 8.03) × 1012kU / L after treatment, respectively, which were significantly lower than those before treatment P <0.01). However, severity of cerebrospinal fluid levels IL 6 between the levels of no significant difference. Conclusion IL 6 participates in the pathological process of GBS, but it has no significant relationship with severity.