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目的采用Meta分析的方法评价肿瘤坏死因子α(TNF-α)基因启动子-308 G/A位点多态性与中国人群强直性脊柱炎(AS)的相关性。方法计算机检索Pub Med、EMbase、CNKI、CBM、Wan Fang Data及VIP数据库,搜集国内外关于TNF-α基因启动子-308 G/A多态性与中国人群AS相关性的病例-对照研究,检索时限均为建库至2015年12月。由2位研究者独立进行文献筛选、资料提取及纳入研究的偏倚风险评价后,采用Stata 12.0软件行Meta分析。结果最终纳入11个病例-对照研究,包括1 154例AS病例,1 458例对照。Meta分析结果显示:对于中国人群,TNG-α基因-308 G/A位点多态性与AS发病风险相关性无统计学意义[A vs.G:OR=0.96,95%CI(0.63,1.47),P=0.86;AA vs.AG:OR=0.97,95%CI(0.51,1.84),P=0.93;AA vs.GG:OR=0.92,95%CI(0.32,2.61),P=0.87;AA+AG vs.GG:OR=1.04,95%CI(0.60,1.80),P=0.89;AA vs.AG+GG:OR=1.03,95%CI(0.58,1.82),P=0.92]。结论尚不能认为TNF-α基因启动子-308 G/A多态性与中国人群AS发病有关。受纳入研究数量及质量的限制,该结论仍需开展相关研究进行验证。
Objective To evaluate the association between TNF-α gene promoter-308 G / A polymorphism and Chinese ankylosing spondylitis (AS) using Meta-analysis. Methods PubMed, EMbase, CNKI, CBM, Wan Fang Data and VIP databases were searched by computer. A case-control study was conducted to find out the correlation between TNF-α gene promoter-308 G / A polymorphism and Chinese AS. Time limit is to build the library until December 2015. Two researchers independently screened the literature, extracted data and included in the study of risk assessment of bias, using Stata 12.0 software Meta-analysis. Results The final 11 case-control studies included 1 154 AS cases and 1 458 controls. The results of Meta analysis showed that there was no significant correlation between the -308G / A polymorphism of TNG-α gene and the risk of AS in Chinese population [A vs. G: OR = 0.96,95% CI (0.63,1.47 ), P = 0.86; AA vs.AG:OR=0.97,95%CI(0.51,1.84),P=0.93;AA vs.GG:OR=0.92,95%CI(0.32,2.61),P=0.87; AA + AG vs.GG: OR = 1.04, 95% CI (0.60, 1.80), P = 0.89; AA vs. AG + GG: OR = 1.03, 95% CI (0.58, 1.82), P = 0.92]. Conclusion The TNF-α gene promoter-308 G / A polymorphism can not be considered as related to the pathogenesis of AS in Chinese population. Due to the limitation of the quantity and quality of the research, this conclusion still needs to be verified by related research.