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茶碱作为支气管扩张药广泛用于治疗哮喘,但有引起心悸、中枢兴奋等副作用。而柴胡加龙骨牡蛎汤(TJ-12)可对具有心悸、失眠、烦躁等神经、精神症状的高血压,以及神经性心动过速、癔病等有改善症状的作用。本次为了明确TJ-12对中枢神经系统的作用,以茶碱所致的自发运动增强小鼠探讨了TJ-12对茶碱中枢兴奋作用的影响。
Theophylline is widely used as a bronchodilator in the treatment of asthma, but it can cause side effects such as palpitations and central nervous excitement. The Chaihujiao oyster soup (TJ-12) can improve the symptoms of hypertension, such as palpitation, insomnia, irritability and other neurological and psychiatric symptoms, as well as nervous tachycardia and rickets. In order to clarify the role of TJ-12 in the central nervous system, the effect of TJ-12 on the stimulatory effects of theophylline central nervous system was investigated using theophylline-induced spontaneous motor enhancement mice.