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麝香酮(即3-甲基十五环酮)是天然麝香的主要成分之一。近年来上海和山东分别用芥子酸和十二烷二酸合成了麝香酮,并证明人工合成的麝香酮具有天然麝香的某些主要药理作用。[~3H]-麝香酮静脉注射或灌胃给药后,经肠道粘膜吸收及血液循环能很快分布到各主要脏器,尤其能迅速通过血脑屏障,而且在中枢神经系统中蓄积时间较长,并主要以原形药排出。为进一步确定[~3H]-麝香酮在细胞水平上的定位分布,我们对[~3H]-麝香酮进行了显微放射自显影研究。
Musk ketone (ie 3-methyl pentadecadione) is one of the main components of natural musk. In recent years, Shanghai and Shandong have synthesized musk ketone with erucic acid and dodecanedioic acid, respectively, and proved that the synthetic musk ketone has some major pharmacological effects of natural musk. [~ 3H] -Morphine intravenous or intragastric administration, the intestinal mucosal absorption and blood circulation can be quickly distributed to all major organs, especially rapidly through the blood-brain barrier, but also in the central nervous system, the accumulation of time Longer, and mainly excreted by prototype drugs. To further determine the cellular localization of [~ 3H] - muscone, we performed a microautographic autoradiography of [~ 3H] - muscone.