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合成抗疟药通常认为始于发现亚甲蓝对疟疾病人具有化疗作用。鉴于亚甲蓝的一个甲基被二烃氨烃基侧链取代后活性的增加以及8一氨基隆附具有杀裂殖体的活性,由此导致第一个合成抗疟药——朴疟喀琳的产生。经证实,8一氨基喷淋是强组织裂殖体杀灭剂。但早期的评价仅以杀血液裂殖体为依据,因此,在讨论8一氨基隆琳类抗疟药的抗组织裂殖体活性的构一效关系之前,可能需要对许多早期资料进行重新评价。
Synthetic antimalarial drugs are generally considered starting from the discovery that methylene blue has a chemogenic effect on malaria patients. Given the increased activity of one methylene group of methylene blue by the sidechain of the dihydrocarbyl amino group and the schizophrenic activity of the 8-aminoanion, the first synthetic malaria drug, The production. It has been confirmed that 8-amino-spray is a strong organization schizonts the killing agent. However, earlier evaluations were based solely on schizonts of schistosomula, and therefore many early data may need to be reassessed before discussing the structural relationship between the antiapoptotic activity of the azamil-type antimalarial drug .