目的观察急性八角枫中毒小鼠器官组织病理学变化并探讨其中毒机制。方法应用八角枫须根水煎液对小鼠灌胃急性染毒,提取组织器官经HE染色后进行病理学观察。结果实验组主要病理改变为肺泡腔出血、肺间质出血,肝窦扩张、淤血,肝细胞水肿,蛛网膜下腔出血,其他器官呈淤血、出血性改变。结论八角枫毒性作用的主要靶器官或靶组织为肺、肝和血管平滑肌;毒性作用与剂量具有相关性。 Objective To observe the histopathological changes and the mechanism of poisoning in the mice induced by acute maple syrup. Methods The mice were orally gavaged with decocted Maple Leaf Decoction. The tissues and organs were harvested and stained with HE for pathological observation. Results The main pathological changes in the experimental group were alveolar hemorrhage, interstitial hemorrhage, sinusoidal dilation, congestion, hepatocellular edema and subarachnoid hemorrhage. Other organs showed congestion and hemorrhagic changes. Conclusion The main target organ or target tissue of the toxic effects of the star anise maple is lung, liver and vascular smooth muscle; the toxic effect is related to the dosage.