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当前对肿瘤发生及发展的研究主要集中在促凋亡与抑凋亡因素调节失衡方面。细胞凋亡的抑制与恶性肿瘤的发生发展以及化疗、放疗不敏感有密切关系。对细胞凋亡抑制基因的深入研究已成为分子肿瘤学的一个热点。Survivin是新近克隆出的凋亡抑制蛋白 (IAP)家族的新成员 ,1997年由Alt
The current research on tumorigenesis and development mainly focuses on the imbalance between the pro-apoptotic and anti-apoptotic factors. The inhibition of apoptosis is closely related to the occurrence and development of malignant tumors and the insensitivity to chemotherapy and radiotherapy. In-depth study of apoptosis inhibitory genes has become a hot spot in molecular oncology. Survivin is a newly discovered member of the apoptosis-inhibiting protein (IAP) family recently cloned by Alt