抗组织胺药除了竞争性对抗组织胺外,尚有拮抗乙酰胆硷、阻滞毛细管通透性增高,使血管紧张性加强、解除平滑肌痉挛以及中枢抑制和局部麻醉作用等。近年来随酚噻嗪类药物研究工作的开展,抗组织胺药在亚细胞水平内的作用,相应受到一定的重视;特别对肝脏的保护作用与抗水肿作用的机制,已逐步或正在明确中。本文拟就部分文献进行综述,以供临床参考。 In addition to competitive antihistamines against histamine, there are antagonistic acetylcholine, increased capillary permeability, increased vascular tone, relieve smooth muscle spasm and central and local anesthetic effects. In recent years, with the work of phenothiazines, the role of antihistamine drugs in the subcellular level, the corresponding attention by some; especially for the protection of the liver and anti-edema mechanism has been gradually or are clear . This article intends to review some of the literature for clinical reference.