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作者将含量相同的两种氯霉素(一为結晶粉,另一为棕櫚酸脂混悬剂)按50mg/kg的剂量給新生儿及嬰儿口服,然后用全血的化学测定和血清的微生物测定方法对比地研究了受試者氯霉素的吸收和排泄。对于出生后19—72小时的新生儿口服氯霉素粉末在半小时內就能达到治疗浓度(即每毫升血液內含10微克以上),而用棕櫚酸脂混悬剂则需2小时。两种氯霉素的治疗浓度均可維持36小时,而在6—12小时浓度最高。研究說明棕櫚酸脂混悬剂要在胃腸內水解以后才能吸收,所以达到治疗浓度較慢,
The authors will be the same content of two kinds of chloramphenicol (one crystalline powder, another palmitic acid lipid suspension) at a dose of 50mg / kg to newborns and infants, and then with the whole blood of the chemical assay and serum microorganisms The assay compares the absorption and excretion of chloramphenicol in subjects. Oral chloramphenicol powder for newborns 19-72 hours after birth achieves therapeutic concentrations (ie more than 10 micrograms per milliliter of blood) in about half an hour, compared with 2 hours for palmitic acid suspensions. The two chloramphenicol treatment concentrations can be maintained for 36 hours, while the highest concentration in 6-12 hours. Studies have shown that palmitate suspension to be hydrolyzed in the gastrointestinal after absorption, so to achieve a slower therapeutic concentration,