论文部分内容阅读
目的:研究过敏性紫癜(HSP)患儿D-Ⅱ聚体的变化及临床意义。方法:选取HSP患儿402例(HSP组),正常健康儿童40例(对照组),采用免疫夹心法和荧光检测法结合检测血浆中的D-Ⅱ聚体含量。再将HSP组按照临床表现分为4组,Ⅰ组仅有皮肤症状、Ⅱ组皮肤症状+关节症状、Ⅲ组皮肤症状+关节症状+消化道症状、Ⅳ组皮肤症状+关节症状+消化道症状+肾脏表现。比较各组D-Ⅱ聚体含量的差别。结果:HSP组血浆D-Ⅱ聚体含量明显高于对照组,P<0.01,差异有统计学意义;Ⅲ组、Ⅳ组D-Ⅱ聚体含量明显高于Ⅰ组、Ⅱ组,P<0.01,差异有统计学意义;Ⅲ组、Ⅳ组D-Ⅱ聚体含量差异无统计学意义,Ⅰ组、Ⅱ组D-Ⅱ聚体含量差异无统计学意义。结论:HSP患儿血浆D-Ⅱ聚体明显升高,提示HSP患儿体内存在高凝状态,随病情严重程度逐渐升高,D-Ⅱ聚体可以作为HSP严重程度的指标之一。
Objective: To study the changes and clinical significance of D-dimer in children with Henoch-Schonlein purpura (HSP). Methods: 402 children with HSP (HSP group) and 40 healthy children (control group) were selected. The content of D-dimer in plasma was detected by immunostaining and fluorescence detection. The HSP group was divided into 4 groups according to the clinical manifestations. The group Ⅰ had only the skin symptoms, the group Ⅱ skin symptoms and joint symptoms, the group Ⅲ skin symptoms and the joint symptoms and gastrointestinal symptoms, the group Ⅳ skin symptoms and the joint symptoms and gastrointestinal symptoms + Kidney performance. The differences of D-dimer content in each group were compared. Results: The content of plasma D-dimer in HSP group was significantly higher than that in control group, P <0.01, the difference was statistically significant. The content of D-dimer in group Ⅲ and group Ⅳ was significantly higher than that in group Ⅰ and group Ⅱ, P <0.01 , The difference was statistically significant. There was no significant difference in the content of D-dimer between group Ⅲ and group Ⅳ, while the content of D-dimer between group Ⅰ and group Ⅱ was not statistically significant. Conclusions: Plasma D-dimer was significantly elevated in children with HSP, suggesting hypercoagulable state in children with HSP. With the severity of the disease increasing, D-dimer could be used as one of the indicators of HSP severity.