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应用ELIB技术观察旋毛虫肌蚴抗原(TsMLSA)与6种寄生虫病人血清的交叉反应。结果表明:TsMLSA中31~100KDa内的蛋白大部分可被急性血吸虫病人血清所识别,而慢性血吸虫病人血清仅识别其中的44/45,51/53,62/64及100KDa蛋白;小于60KDa者可与丝虫病、钩虫病、肺吸虫、蛔虫病和肝吸虫病人血清呈不同程度的交叉反应,以前三者为最明显;45KDa蛋白可被部分正常人血清识别。提示,旋毛虫肌蚴抗原与多种寄生虫有共享成分,但与血吸虫的交叉可依据4组区带用以鉴别诊断此二种寄生虫病。
The ELIB technique was used to observe the cross-reactivity of the trichomonas laevis antigen (TsMLSA) with the sera of six parasite patients. The results showed that most of the proteins in the range of 31-100 kDa in TsMLSA could be recognized by the serum of acute schistosomiasis patients, whereas the serum of chronic schistosomiasis patients only recognized 44/45, 51/53, 62/64 and 100 kDa proteins; those less than 60 kDa With the filariasis, hookworm disease, paragonimiasis, ascariasis and paragonimiasis serum showed varying degrees of cross-reaction, the former three were the most obvious; 45KDa protein can be recognized by some normal human serum. Tip, Trichinella anti-sporozoite antigen and a variety of parasites have shared components, but the cross with the schistosome can be based on the four groups of zones for the differential diagnosis of the two parasitic diseases.