论文部分内容阅读
To explore the biological properties of a new neutralmyocardial imaging agent 99mTcN(NOEt)2, preparationand characterization of 99mTcN(NOEt)2, kinetics of blood-drugclearance in rabbits, biodistribution in rats, test of unduetoxicity in mice and myocardial imaging in dogs were performed andvolunteer imaging.Radiochemical purity of 99mTcN(NOEt)2 was over than 90% and stable for 6 hours at room temperature.Blood disappearancewas analyzed with biexponential model,T1/2(α)=2.53min, T1/2(β)=330min and Cl=378mL/h were obtained.Biodistribution studiesdemonstrated that 99mTcN(NOEt)2 localized selectivelyin myocardiumof rats.Cardiac uptake were 2.79, 2.25, 2.00 and 1.88%ID/organ at 5,30, 60 and 90min of postinjection, respectively.The heart-to-lungactivity ratio was 1.16 at 60min.Images showed that pulmonary uptakedecreased faster than cardiac uptake in a dog.The mean heart-to-lungactivity ratios in a dog were 1.69, 2.40 and 2.55 at 10, 30 and 60min of postinjection, respectively.The heart was distinguishableon scans at 30min.Whole body imaging showed that cardiac uptakewas 2.82%ID at 90min, but hepatic uptake was 30%ID and remainedconstant.The test of undue toxicity showed that the dose receivedby mice was 614 times as by human.Volunteer imaging suggests 99mTcN(NOEt)2 redistribution with time.99mTcN(NOEt)2 exhibitedfavorable stabilities, biological properties and safety.It is worth forfurther studying in human.