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近年来国内外对抗瘧药物的研究有了很大的进展。兹就几种抗瘧药物的临床评价作—重点简述,供临床医师参考。一、4—氨基喹啉类:目前已在临床应用的主要有如下四种: 1.氯喹啉(Chloroquine):目前被公认为最优秀的裂殖体杀灭剂。氯喹啉在腸道吸收完全、迅速,磷酸盐几乎达100%;口服0.6克基质在2～3小时内血浆中浓度达到或超过有效水平;肌肉注射15分钟后即达到有效水平;组织中浓度比血浆中高200～700倍。氯喹啉的代谢与排泄都很缓慢,故其血浆有效浓
In recent years, domestic and foreign research on antimalarial drugs has made great progress. Here are some of the clinical evaluation of antimalarial drugs - a brief overview for the clinician’s reference. A 4-aminoquinolines: There are currently four main clinical applications: 1. Chloroquine (Chloroquine): currently recognized as the best schizophrenic agent. Chloroquinoline absorption in the intestine is complete and rapid, phosphate almost 100%; oral 0.6 grams of matrix in 2 to 3 hours plasma concentration reached or exceeded the effective level; 15 minutes after intramuscular injection to achieve an effective level; tissue concentration ratio High plasma 200 to 700 times. Chloroquinoline metabolism and excretion are very slow, so its effective plasma concentration