随着社会经济的发展,糖尿病正在日益成为威胁人类健康的主要杀手,在终末期肾功能衰竭的患者中,糖尿病肾病(DN)所占比例逐年增加。细胞外基质(ECM)堆积是DN病理损害的关键,ECM降解及合成失调是肾小球硬化发生重要因素。DN发病机理复杂,近年来临床和动物实验证明许多细胞生长因子 As socio-economic development, diabetes is increasingly becoming a major killer of human health, and in patients with end-stage renal failure, the proportion of diabetic nephropathy (DN) is increasing year by year. Accumulation of extracellular matrix (ECM) is the key to pathological damage of DN, ECM degradation and synthesis disorders are important factors of glomerulosclerosis. DN pathogenesis is complex, in recent years, clinical and animal experiments proved that many cell growth factors