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目的:探讨分析炎症因子C反应蛋白(CRP)、淀粉样蛋白A(SAA)联合癌胚抗原(CEA)、糖类抗原242(CA242)、糖类抗原50(CA50)检测对结肠癌的诊断价值。方法:收集中国科学院大学附属肿瘤医院2019年1月至6月177例首诊结肠癌患者、74例结肠息肉患者和58例健康体检者分为结肠癌组、结肠息肉组和健康对照组，分析各组CRP、SAA、CEA、CA242、CA50水平并计算其诊断结肠癌的效率，比较不同分期结肠癌的相应水平。结果:结肠癌组CRP、SAA、CEA、CA242、CA50水平较结肠息肉组、健康对照组明显升高(n P<0.05)；结肠息肉组CRP、SAA、CEA水平较健康对照组明显升高(n P<0.05)。CRP、SAA、CEA、CA242、CA50联合诊断结肠癌的AUC为0.818，灵敏度和特异度均高于单独检测。Ⅳ期结肠癌CRP、SAA、CEA、CA242、CA50水平较0~Ⅲ期明显增高(n P<0.05)。n 结论:炎症因子CRP、SAA联合CEA、CA242、CA50可以提高结肠癌的诊断效率，并有助于结肠癌病情的判断，尤其对伴远处转移的Ⅳ期结肠癌的诊断意义较大。“,”Objective:To analyze the value of combined detection of C reactive protein (CRP), serum amyloid A (SAA), carcinoembryonic antigen (CEA), carbohydrate antigen (CA)242, CA50 in the diagnosis of colon cancer.Methods:177 inpatients with first-diagnosed colon cancer in Cancer Hospital of University of Chinese Academy of Sciences from January 2019 to June 2019, 74 patients with non-cancerous colonic polyps, 58 healthy subjects were respectively collected as colon cancer group, colonic polyps group and healthy control group. The levels of CRP, SAA, CEA, CA242 and CA50 in each group were compared and the diagnostic efficiency was calculated. The significance in different stages of colon cancer was evaluated.Results:The levels of CRP, SAA, CEA, CA242 and CA50 in colon cancer group were significantly higher than those in colonic polyps group and healthy control group (n P<0.05); the levels of CRP, SAA and CEA in colonic polyps group were significantly higher than those in healthy control group (n P<0.05). The area under the curve (AUC) of CRP, SAA, CEA, CA242 and CA50 in the diagnosis of colon cancer was 0.818, and the sensitivity and specificity were higher than those of single detection (n P<0.05). The levels of CRP, SAA, CEA, CA242 and CA50 in stage Ⅳ colon cancer were significantly higher than those in stage 0-Ⅲ (n P<0.05).n Conclusions:The combined detection of CRP, SAA, CEA, CA242, CA50 can improve diagnostic efficiency of colon cancer. Besides, the detected levels of CRP, SAA, CEA, CA242 and CA50 are helpful to the diagnosis of colon cancer, especially in stage Ⅳ colon cancer with distant metastasis.