与其他结缔组织疾病相反,硬皮病引起神经系统病变特别是累及颅神经者罕见。Beighton 等首次报导1例硬皮病伴发三叉神经感觉性神经病,Ashworth 等和 Kaltreider 等相继分别观察了5和3例硬皮病并发三叉神经感觉性神经病。作者观察了10例(男2、女8)确诊为硬皮病的患者均有颅神经的侵犯,年龄33～63岁,分别于硬皮病诊断的同时或晚至15年内出现三叉神经感觉性神 Contrary to other connective tissue diseases, it is uncommon for scleroderma to cause neurological disorders, especially those involving cranial nerves. Beighton and others first reported 1 case of scleroderma with trigeminal neuropathic neuropathy, Ashworth et al and Kaltreider were observed in 5 and 3 cases of scleroderma with trigeminal nerve sensory neuropathy. The authors observed that 10 patients (male 2, female 8) were diagnosed as scleroderma patients have cranial nerve violations, aged 33 to 63 years old, respectively, in the diagnosis of scleroderma or 15 to 15 years later, trigeminal nerve sensation God