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目的 :探讨 Pras2 1在胃癌细胞学诊断中的临床意义。方法 :采用免疫组化单克隆抗体方法检测细胞刷检中的 ras基因产物 P2 1。结果 :取自正常胃粘膜或良性病变的 2 8例胃良性上皮细胞中有2 6例呈阴性反应 ,仅有 2例胃溃疡病变呈弱阳性反应。58例胃癌中的 50例呈阳性反应而且与组织分化程度无关。结论 :免疫组化方法检测 Pras2 1可能成为一种新的组织学诊断手段。
Objective: To investigate the clinical significance of Pras2 1 in cytological diagnosis of gastric cancer. Methods: The ras gene product P2 1 was detected by immunohistochemical monoclonal antibody. RESULTS: Twenty-six of 28 gastric benign epithelial cells from normal gastric mucosa or benign lesions were negative and only two of them had a weak positive reaction. Fifty-eight cases of gastric cancer were positive in 50 cases and had no relation with the degree of tissue differentiation. Conclusion: Immunohistochemical detection of Pras2 1 may be a new diagnostic tool for histology.