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目的分析妊娠期甲状腺功能减退对妊娠结局的影响及药物干预效果。方法 210例妊娠期甲状腺功能减退患者作为研究对象,随机分为实验组(110例)与对照组(100例),实验组患者按照医嘱采取左甲状腺素钠片治疗,对照组患者未接受左甲状腺素钠片治疗。100例体检健康孕妇设为正常组,对比三组孕妇并发症情况及胎儿不良结局情况。结果实验组与正常组贫血、胎盘早剥、前置胎盘、流产、早产发生率比较差异均无统计学意义(P>0.05),实验组及正常组贫血(4.5%、4.0%)、胎盘早剥(1.8%、2.0%)、前置胎盘(1.8%、1.0%)、流产(2.7%、4.0%)、早产发生率(1.8%、2.0%)均低于对照组14.0%、11.0%、13.0%、15.0%、13.0%,差异均具有统计学意义(P<0.05)。实验组与正常组胎儿窘迫、低体重儿、新生儿患病率比较差异均无统计学意义(P>0.05),实验组及正常组胎儿窘迫(1.8%、1.0%)、低体重儿(10.0%、10.0%)、新生儿患病率(7.3%、7.0%)均低于对照组8.0%、21.0%、16.0%,差异均具有统计学意义(P<0.05)。结论妊娠期甲状腺功能减退不利于患者的妊娠结局,需要及时进行治疗,才能有效的提高预后,因此要重视在妊娠早期进行常规的甲状腺功能检查,才能及时的发现疾病,进而进行治疗。
Objective To analyze the effect of hypothyroidism during pregnancy on the outcome of pregnancy and the effect of drug intervention. Methods Totally 210 pregnant women with hypothyroidism during pregnancy were randomly divided into experimental group (n = 110) and control group (n = 100). Patients in the experimental group were treated with levothyroxine sodium according to doctor’s advice, and patients in the control group did not receive left thyroid Sodium tablets treatment. 100 healthy pregnant women as normal control group, compared with three groups of pregnant women complications and fetal adverse outcomes. Results There was no significant difference in the incidence of anemia, placental abruption, placenta previa, miscarriage and preterm labor between the experimental group and the normal group (P> 0.05). The anemia in the experimental group and normal group (4.5%, 4.0% (1.8%, 2.0%), placenta previa (1.8%, 1.0%), abortion (2.7%, 4.0%) and preterm birth (1.8%, 2.0%) were lower than the control group by 14.0% and 11.0% 13.0%, 15.0% and 13.0%, respectively, with statistical significance (P <0.05). There was no significant difference in the prevalence of fetal distress, low birth weight infants and newborn infants between the experimental group and the normal group (P> 0.05), and the incidence of fetal distress (1.8%, 1.0%) and low birth weight infants %, 10.0%). The prevalence of neonates (7.3%, 7.0%) was lower than that of the control group by 8.0%, 21.0% and 16.0% respectively. The difference was statistically significant (P <0.05). Conclusion Pregnancy hypothyroidism is not conducive to the patient’s pregnancy outcome, the need for timely treatment in order to effectively improve the prognosis, it should pay attention to the routine thyroid function tests in early pregnancy, in order to timely detection of the disease, and then for treatment.