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新生儿重症监护室是受耐药菌群繁殖、感染和播散的高危区,早期、准确的诊断可以指导临床合理使用抗生素。现行的临床诊断指标如C反应蛋白(CRP)、中性粒细胞计数等尚不够敏感。近年来细胞因子,尤其是TNF-α、IL-6和IL-8等成为新生儿菌血症的潜在诊断指标。目前关于以上3种细胞因子在新生儿菌血症中的诊断价值报道较多,作者经过严格筛选,剔除未明确诊断的11篇报道,综合分析评价20篇报道的研究可信度、细胞因子检测的精确性以及临床应用。
The neonatal intensive care unit is a high-risk area where the drug-resistant flora multiplies, infects and disperses. Early and accurate diagnosis can guide the clinical rational use of antibiotics. The current clinical diagnostic criteria such as C-reactive protein (CRP), neutrophil count is not sensitive enough. In recent years, cytokines, especially TNF-α, IL-6 and IL-8 as potential diagnostic indicators of neonatal bacteremia. Currently on the three kinds of cytokines in the diagnosis of neonatal bacteremia more value, the author undergo a rigorous screening, excluding undefined diagnosis of 11 articles, a comprehensive analysis of 20 reports of the study reported credibility, cytokine detection Accuracy and clinical application.