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目的:探讨非靶器官肿瘤(原发性支气管肺癌)是否存在雌激素(estrogen receptor ER)、孕激素受体(progesterone recep-tor.PR)及ER、PR与肿瘤的关系,方法:146例手术切除原发性支气管肺癌标本,按WHO肺癌组织学分类标准进行光镜诊断;运用免疫组织化学ABC法进行石蜡切片的ER,PR检测 结果:ER阳性检出率58.9%,PR阳性检出率69.1,双阳46.6%.提示雌孕激素受体阳性率与肿瘤分化程度呈正相关、与组织学类型、肿块大小、患者年龄、性别无关 结论:非小细胞肺癌组织中存在性激素受体,将其作为激素辅助治疗的一个指标,有一定的应用前景.
Objective: To investigate the relationship between estrogen (estrogen receptor ER), progesterone receptor (PR) receptor, and ER, PR and tumor in non-target tumors (primary bronchial lung cancer). Methods: 146 cases The primary bronchial lung cancer specimens were resected and light microscopy was performed according to the histological classification criteria of WHO lung cancer. The ER and PR results of paraffin sections using immunohistochemical ABC method were: ER positive detection rate was 58.9%, and PR positive detection rate was 69.1. , Shuangyang 46.6%. The positive rate of estrogen and progesterone receptors was positively correlated with the degree of tumor differentiation, and was not related to histological type, tumor size, patient age, gender. Conclusion: The presence of sex hormone receptors in non-small cell lung cancer tissues as a hormone An indicator of adjuvant therapy has a certain application prospect.