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特发性血小板减少性紫癜(idiopathic thrombo-cytopenic purpura,ITP)是一种原因不明、因血小板破坏过多伴巨核细胞成熟障碍引起的获得性出血性疾病,发病与血小板特异性自身抗体相关,由于发病机制尚未明确,临床治疗针对性差、效果欠佳。已发现细菌感染是影响ITP发病的重要因素之一,近年来报道幽门螺杆菌(Helicobacterpylori,HP)感染与部分ITP发病有关,根除HP对HP阳性ITP患者改善临床症状及血象恢复、激素治疗都具有显著效果,但也出现二者无明显相关的报道。两者的关联机制尚不明确。
Idiopathic thrombocytopenic purpura (idiopathic thrombo-cytopenic purpura, ITP) is an unexplained, due to excessive destruction of platelets accompanied by megakaryocyte maturation disorders with acquired hemorrhagic disease, the incidence of platelet-specific autoantibodies, due to The pathogenesis is not yet clear, the clinical treatment of poor, poor results. It has been found that bacterial infection is one of the important factors that affect the pathogenesis of ITP. In recent years, it is reported that Helicobacter pylori (HP) infection is related to the pathogenesis of some ITP. Eradication of HP improves the clinical symptoms and blood picture recovery in patients with HP-positive ITP. Significant effect, but there is no obvious correlation between the two reports. The relationship between the two mechanisms is not yet clear.