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近年研究表明,一些小的双链RNA可以高效特异地阻断体内基因表达,促进RNA降解,在细胞内发挥基因敲除作用,这种现象被称为RNA干扰(RNAi)[1]。RNAi技术已被广泛应用于治疗病毒、癌症等疾病的研究。本研究旨在探讨RNAi技术抗HBV的可行性,从而为RNAi治疗乙型肝炎提供实验基础。
In recent years, studies have shown that some small double-stranded RNA can efficiently and specifically block the gene expression in vivo, promote RNA degradation, and exert a knockout effect in the cell. This phenomenon is called RNA interference (RNAi) [1]. RNAi technology has been widely used in the treatment of diseases such as viruses and cancer. This study aimed to explore the feasibility of anti-HBV RNAi technology, thus providing the experimental basis for the treatment of hepatitis B RNAi.