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目的： 研究单硝酸异山梨酯的抗心肌缺血及耐缺氧作用， 并与进口单硝酸异山梨酯及国产消心痛进行比较。方法： 采用药物诱发心肌缺血法及冠状动脉结扎法。结果： 国产单硝酸异山梨酯对垂体后叶素诱发的心肌缺血， 对家兔冠状动脉结扎所致的心肌缺血均有明显的保护作用， 可明显延长常压缺氧、异丙肾上腺素诱发缺氧小鼠的生存时间。结论： 国产单硝酸异山梨酯的抗心肌缺血作用与进口单硝酸异山梨酯及国产消心痛作用相近。
Objective: To study the effect of isosorbide mononitrate on myocardial ischemia and hypoxia tolerance, and compared with imported isosorbide mononitrate and domestic eclampsia. Methods: Drug-induced myocardial ischemia and coronary ligation. Results: Isosorbide mononitrate had obvious protective effect on vasopressin-induced myocardial ischemia and myocardial ischemia induced by coronary artery ligation in rabbits, which could prolong the effect of normobaric hypoxia and isoproterenol Induced hypoxic mice survival time. Conclusion: The effect of isosorbide mononitrate on myocardial ischemia is similar to that of isosorbide dinitrate and domestic heartburn.