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目的探讨N末端B型钠尿肽前体(NT-pro BNP)水平与孕妇是否合并心脏病的相关性。方法选取妊娠合并心脏病孕妇74例和同期正常妊娠孕妇80人,两组分别检测晚妊期NT-pro BNP血浆浓度并作比较,其中正常妊娠孕妇组还检测早妊期NT-pro BNP血浆浓度,分别与该组晚妊期结果比较,同时对妊娠合并心脏病孕妇作心功能分级,并与晚妊期血浆NT-pro BNP水平作关联性分析。结果妊娠合并心脏病孕妇NT-pro BNP血浆浓度(中位数为352.50 pg/m L,浓度范围为84.00~3 806.00 pg/m L)明显高于正常妊娠孕妇晚妊期(中位数为58.00 pg/m L,浓度范围为26.00~164.00 pg/m L)(P<0.01),其心功能分级越高,NT-pro BNP血浆浓度水平也越高(P<0.01);正常妊娠孕妇的晚妊期NT-pro BNP血浆浓度高于早妊期(中位数为49.00 pg/m L,浓度范围为20.00~178.00 pg/m L)(P<0.01)。结论 NT-pro BNP血浆浓度水平在评价合并心脏病孕妇心功能受损程度有重要的临床应用价值,妊娠对正常孕妇心功能有一定的影响。
Objective To investigate the relationship between N-terminal proBNP level (NT-pro BNP) and pregnant women with or without heart disease. Methods 74 pregnant women with pregnancy complicated by heart disease and 80 normal pregnancy women were enrolled in this study. Plasma concentrations of NT-pro BNP in late pregnancy were measured and compared. The plasma levels of NT-pro BNP in early pregnancy , Respectively, compared with the results of late pregnancy in this group, at the same time for pregnant women with heart disease complicated by heart function grading, and with late pregnancy plasma NT-pro BNP level for the correlation analysis. Results Plasma concentrations of NT-pro BNP in pregnant women with heart disease complicated with heart disease (median 352.50 pg / m L, concentration range 84.00-3806.00 pg / m L) were significantly higher than those of normal pregnant women (median 58.00 (P <0.01). The higher the level of cardiac function was, the higher the plasma concentration of NT-pro BNP was (p <0.01). The later of normal pregnant women Plasma NT-pro BNP plasma levels during pregnancy were higher than those at early pregnancy (median, 49.00 pg / m L, 20.00-178.00 pg / m L) (P <0.01). Conclusion The plasma concentration of NT-pro BNP has important clinical value in assessing the degree of cardiac dysfunction in pregnant women with heart disease. Pregnancy has a certain impact on the heart function of normal pregnant women.