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目的:探讨维吾尔族原发性干燥综合征(PSS)肾损害的临床与病理特征,提高对本病的认识。方法:对21例PSS肾损害患者进行肾活检,并与临床、实验室检查进行对比分析。结果:17例为I型肾小管酸中毒(1型RTA),5例合并低钾性麻痹。5例合并骨质疏松或病理性骨折,2例并泌尿系结石。肾病综合征及肾小球,肾炎(GN)分别为3及2例。免疫病理12例阳性,肾小球基底膜及系膜区主见IgG、IgA、rgM及C3沉积病理示慢性间质性肾炎13例,肾小球肾炎13例。结论:PSS肾损害时,肾小球肾炎并非罕见,应重视。
Objective: To investigate the clinical and pathological features of Uygur Sjogren’s syndrome (PSS) nephropathy and to improve the understanding of this disease. Methods: Twenty-one PSS patients with renal damage underwent renal biopsy and compared with clinical and laboratory tests. Results: Twenty-seven were type I renal tubular acidosis (type 1 RTA) and 5 were hypokalemic paralysis. 5 cases with osteoporosis or pathological fracture, 2 cases and urinary calculi. Nephrotic syndrome and glomerular, nephritis (GN) were 3 and 2 cases. Immunopathology in 12 cases of positive, glomerular basement membrane and mesangial area main see IgG, IgA, rgM and C3 deposition pathology showed chronic interstitial nephritis in 13 cases, 13 cases of glomerulonephritis. Conclusion: When PSS is damaged by kidney, glomerulonephritis is not uncommon and should be taken seriously.